RU2394811C2 - Method of producing acetamidine.
This paper introduces the improvement of acetamidine hydrochloride synthesis,and compared with the traditional process,this process is the most ideal one with lower energy consumption and high final yield, high economic benefit. Download(CAJ format) Download(PDF format).General synthesis of compounds 9-14 Compounds 3-8 (0.65 mmol) were dissolved in a mixture of dioxane (38 mL) and HCl 4N (5 mL) and stirred for 24 h. Then solvent was removed under reduced pressure and a white, hygroscopic solid was obtained in quantitative yield.Acetamidine hydrochloride is extracted through filtration from ammonium chloride and distillation of the solvent mixture until formation of a suspension, filtration and washing the residue with cold alcohol. Before distillation of the solvent mixture, the mother solution and the washing alcohol are returned to the reaction mixture.
Synthesis of amidines. Recent Literature. The condensation of primary amine with N,N-dimethylacetamide dimethyl acetal yields a mixture of acetamidine and imidate ester depending on the temperature, solvent, and structure of the primary amine.Under catalyst-free conditions, an efficient method for the synthesis of 2-aminopyridine derivatives through the nucleophilic substitution and hydrolysis of 2-fluoropyridine and acetamidine hydrochloride has been developed. This amination uses inexpensive acetamidine hydrochloride as the ammonia source and h Synthetic methodology in OBC.
Learn more about Glucosamine Hydrochloride uses, effectiveness, possible side effects, interactions, dosage, user ratings and products that contain Glucosamine Hydrochloride.
